Cibenzoline
CAS No. : 53267-01-9
(Synonyms: Cifenline; Ro 22-7796)
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $640 | In-stock |
| 100mg | $1050 | In-stock |
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| Cat. No. : | HY-106577 |
| M.Wt: | 262.36 |
| Formula: | C18H18N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia[1][2][3][4].
IC50 & Target:KATP channel[1]
In Vitro:Cibenzoline (1-100 μM; 3-5 min) inhibits the spontaneous activity and leads to sinus arrest in rat sino-atrial nodal cells[1].
Cibenzoline (3-300 μM; 15 minutes) inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM in rat sino-atrial nodal cells[1].
In Vivo:Cibenzoline (5-20 mg/kg; intravenous injection; single dose) has hypoglycemic effect in rats[2].
Pharmacokinetic Analysis in Rats[2]
| Route | Dose (mg/kg) | k12 (h-1) | k21 (h-1) | Vc (L/kg) | Vmax, CBZ (μg/h) | Km, CBZ (μg/L) |
| i.v. | 5, 10 and 20 | 1.93 | 1.01 | 4.70 | 32391 | 3554 |