Pinaverium bromide
CAS No. : 53251-94-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $70 | In-stock |
| 50mg | $90 | In-stock |
| 100mg | $130 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111613 |
| M.Wt: | 591.42 |
| Formula: | C26H41Br2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].
IC50 & Target:Calcium channel[1].
In Vitro:Pinaverium bromide (0-30 μM, 24 h) inhibits GM-CSF or CXCL1/CXCL2 induced neutrophil migration, and inhibits ROS production in the presence of 0.1 ng/mL GM-CSF in purified neutrophils from mouse bone marrow[2].
Pinaverium bromide (3 μM, 16 h) inhibits the GM-CSF induced expression of cytokines (IL-1β, IL-6, and TNF-α) in primed neutrophils from mouse bone marrow[2].
Pinaverium bromide inhibits the contractile response to ACh or KCl in the control or stressed colonic circular muscle, with IC50s of 1.66 and 0.91 μM respectively[3].
In Vivo:Pinaverium bromide (1-10 mg/kg, i.p.) inhibits excessive systemic inflammation in Lipopolysaccharide (HY-D1056)-induced mice[2].
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