Coixol
CAS No. : 532-91-2
(Synonyms: 6-Methoxy-2-benzoxazolinone; 6-MBOA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $30 | In-stock |
| 25mg | $60 | In-stock |
| 50mg | $85 | In-stock |
| 100mg | $110 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0936 |
| M.Wt: | 165.15 |
| Formula: | C8H7NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3].
In Vitro:Coixol (5, 10, 20 µM, 2+24 h) decreases the iNOS protein expression in LPS-induced RAW264.7 Cells[2].
Coixol (0.03, 0.1, 0.3, 1, 3, 10, 30, 100 μM; 1+24 h) inhibits the production of TNF-α, IL-6, and IL-1β with IC50s of 31.2, 48.9, 66.4 µM, respectively[2].
In Vivo:Coixol (25, 50 mg/kg, p.o.) improves glucose tolerance and stimulates glucose-induced plasma insulin in non-diabetic and diabetic rats[3].
Coixol (25, 50 mg/kg, p.o.; daily for 15 day) decreases the blood glucose levels in a dose- and time-dependent manner in type 2 diabetic rats[3].
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