Benzoyl isothiocyanate

Benzoyl isothiocyanate is an aromatic isothiocyanate derivative with antibacterial and acaricidal activities. Benzoyl isothiocyanate inhibits the growth of specific oral bacteria, and also serves as an intermediate for the synthesis of heterocyclic compounds such as thiazolidine and quinazoline derivatives. Benzoyl isothiocyanate exhibits acaricidal activity against Dermatophagoides farina (dust mite) and D. pteronyssinus (house dust mite). Benzoyl isothiocyanate can be used in research related to bacterial infection, pest control and organic synthesis^[1][2][3]. In Vitro:Benzoyl isothiocyanate can react with various arylamine substrates to form thiourea intermediates, which can be converted into a series of heterocyclic products including thiazolidines, oxazolidines, imidazolidinones, thiazines and tetrahydroquinazolines via desulfurization, acid cyclization and other transformations^[1].
Benzoyl isothiocyanate (0.10-5.0 mg/disc; 2 days) potently inhibits the growth of Clostridioides difficile ATCC 9689, Clostridium perfringens ATCC 13124, and Escherichia coli ATCC 11775 at the dose of 5.0 mg/disc, with its activity decreasing in a dose-dependent manner: it only exerts weak inhibitory effects on the three strains mentioned above at 0.25 mg/disc; at 0.10 mg/disc, it only shows weak inhibitory effects on Clostridium strains but has no inhibitory effect on E. coli^[2].
Benzoyl isothiocyanate (0.05-2.0 mg/disc; 2 days) exerts dose-dependent anaerobic growth inhibitory effects against Porphyromonas asaccharolytica ATCC 25260, Porphyromonas gingivalis ATCC 33277, Streptococcus sobrinus ATCC 27607, and Streptococcus mutans ATCC 25175^[3].
Benzoyl isothiocyanate exhibits acaricidal activity against Dermatophagoides farina (house dust mite) and D. pteronyssinus (European house dust mite), with LD₅₀ values of 13.8 and 7.63 µg/cm² respectively^[4].