Euparin

Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects^[1][2]. In Vitro: In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC₅₀ values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively^[1]. In Vivo: Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression^[2].