Myosmine
CAS No. : 532-12-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $10 | In-stock |
| 250mg | $12 | In-stock |
| 1g | $18 | In-stock |
| 5g | $22 | In-stock |
| 10g | $26 | In-stock |
| 25g | $48 | In-stock |
| 100g | $120 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-W001909 |
| M.Wt: | 146.19 |
| Formula: | C9H10N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2]. IC50 & Target: Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1] In Vitro: Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2]. In Vivo: Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2].
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