Trolox (GMP)

Trolox (GMP) is Trolox (HY-101445) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage^[1][2]. In Vitro:Trolox (GMP) has shown to protect mammalian cells from oxidative damage. Trolox (GMP) is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion^[1].
Trolox (GMP) could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or post-treatment of cells with Trolox (GMP) reduced H₂O₂-induced DNA fragmentation to control levels and below. ^[2].
Trolox (GMP) is a hydrophilic analog of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox (GMP) prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator^[3].