Trolox


CAS No. : 53188-07-1

53188-07-1
Price and Availability of CAS No. : 53188-07-1
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250mg $15 In-stock
1g $19 In-stock
5g $48 In-stock
10g $65 In-stock
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100g $537 In-stock
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Cat. No. : HY-101445
M.Wt: 250.29
Formula: C14H18O4
Purity: >98 %
Solubility: H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 233.33 mg/mL (ultrasonic)
Introduction of 53188-07-1 :

Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2]. In Vitro:Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion[1].
Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or post-treatment of cells with Trolox reduced H2O2-induced DNA fragmentation to control levels and below. [2].
Trolox is a hydrophilic analog of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator[3].

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