Manganese(salen) chloride
CAS No. : 53177-12-1
(Synonyms: EUK-8)
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| Cat. No. : | HY-W001583 |
| M.Wt: | 356.69 |
| Formula: | C16H14ClMnN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2]. In Vitro: Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2]. In Vivo: Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].
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