1-Hydroxypyrene
CAS No. : 5315-79-7
| Size | Price | Stock |
|---|---|---|
| 1g | $10 | In-stock |
| 5g | $13 | In-stock |
| 10g | $22 | In-stock |
| 25g | $54 | In-stock |
| 100g | $215 | In-stock |
| 500g | $1074 | In-stock |
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| Cat. No. : | HY-W014075 |
| M.Wt: | 218.25 |
| Formula: | C16H10O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis[1][2]. IC50 & Target:Endogenous Metabolite[1] In Vitro:1-Hydroxypyrene (10 nM, 12-36 h) inhibits the cell viability of HK-2, increases the expression of AhR, Cyp1a1/Cyp1a2/Cyp1b1, collagen I, α-smooth muscle actin (α-SMA), and fibronectin, maintains the expression of E-cadherin, induces epithelial-mesenchymal transition (EMT) in cell HK-2[2]. In Vivo:1-Hydroxypyrene (250 mg/kg, po, once daily for 4-12 weeks) increases the serum creatinine and urea levels, causing kidney injury and fibrosis in mouse models[2].
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