Scopolin
CAS No. : 531-44-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $220 | In-stock |
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| Cat. No. : | HY-N0341 |
| M.Wt: | 354.31 |
| Formula: | C16H18O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots[1]. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades[2].
In Vitro: Scopolin (100 μM, 24 h) inhibits oleic acid-induced lipid accumulation by increasing SIRT1 activity in HepG2 cells[2].
Scopolin(10 μM, 5 days) inhibits RANKL induced differentiation of preosteoclastic RAW 264.7 cells into osteoclasts[5].
In Vivo: Scopolin (0.02% (w/w) in HFD diet, 8 weeks) decreases the body weight gain, and alleviates hepatic steatosis in HFD-fed mice[2].
Scopolin (2 μmol, icv) increases the extracellular acetylcholine concentration in rat brain to about 300% compared to basal release[3].
Scopolin (50, 100 mg/kg, i.p.) inhibits adjuvant-induced arthritis by inhibiting inflammation and angiogenesis in rats[4].
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