DIDS
CAS No. : 53005-05-3
(Synonyms: MDL101114ZA (free base))
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| Cat. No. : | HY-121693 |
| M.Wt: | 454.52 |
| Formula: | C16H10N2O6S4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].
In Vitro: DIDS (0-10 μM) inhibits RAD51-mediated strand exchange[1].
DIDS (0-20 μM) inhibits DNA binding by RAD51[1].
DIDS (10 μM; 0-60 min) stimulates the ATP hydrolyzing activity of RAD51 in the absence of DNA[1].
DIDS (50-400 μM) prevents effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect, and dose at 400 μM insifnificantly decreases the cell viability[2].
DIDS (100 μM) clearly inhibits caspase-3 and caspase-9 activation[2].
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