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2-Acetamidofluorene


CAS No. : 53-96-3

53-96-3
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Cat. No. : HY-W013514
M.Wt: 223.28
Formula: C15H13NO
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 53-96-3 :

2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours[1][2]. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

2-Acetamidofluorene-induced HCC rat liver tissues has hepatic cell degeneration, oval cell proliferation, and inflammatory cell infiltration[1].
2-Acetylaminofluorene can be used to induce hepatocellular carcinoma (HCC) Model[1][2][3].

Induction of Hepatocellular Carcinoma (HCC) Model[1][2][3]
Background
2-Acetamidofluorene exhibits strong damaging effects on DNA.
Specific Mmodeling Methods
Rat: Sprague-Dawley• 2-mo old• 140-180 g • 0.05% (w/w) • diet fed • 8 weeks
Note
(2). At the end of the 8 weeks, the living rats are then fed with normal granules.
Modeling Indicators
<Histology analysis: Hepatic cell degeneration, oval cell proliferation, and inflammatory cell infiltration.
Correlated Product(s): Carbon tetrachloride (HY-Y0298)

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