5,6-Dichlorobenzimidazole riboside
CAS No. : 53-85-0
(Synonyms: DRB)
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|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $38 | In-stock |
| 25mg | $41 | In-stock |
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| Cat. No. : | HY-14392 |
| M.Wt: | 319.14 |
| Formula: | C12H12Cl2N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis[1][2][3][4][5][6][7].
In Vitro: 5,6-Dichlorobenzimidazole riboside (10-80 μg/mL, 72 h) induces p53-dependent apoptosis of human colon cancer cells by blocking RNA synthesis[5].
5,6-Dichlorobenzimidazole riboside (10-100 μM, 72 h) induces apoptosis of human MCF-7 breast cancer cells by regulating Mcl-1 and BclxL. And activates members of the caspase family in a time - and dose-dependent manner[6].
In Vivo: 5,6-Dichlorobenzimidazole riboside (2.0-3.0 mg/0.25 mL water, intraperitoneally injected twice a day for 5 days) does not inhibit the multiplication of the PR8 strain of influenza virus in mice[7].
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