Paramethasone
CAS No. : 53-33-8
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| Cat. No. : | HY-A0179 |
| M.Wt: | 392.46 |
| Formula: | C22H29FO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Paramethasone is an orally active long-acting glucocorticoid. Paramethasone directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone can be used in research related to osteoarthritis and endocrinology[1][2]. In Vivo:Paramethasone (0.1 mg/kg; i.g.; 5 days per week; 5 weeks) significantly reduces the severity of surgically induced osteoarthritis in male New Zealand white rabbits[2].
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