Crustecdysone


CAS No. : 5289-74-7

(Synonyms: 20-Hydroxyecdysone)

5289-74-7
Price and Availability of CAS No. : 5289-74-7
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10mg $77 In-stock
50mg $237 In-stock
100mg $402 In-stock
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Cat. No. : HY-N6979
M.Wt: 480.63
Formula: C27H44O7
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 5289-74-7 :

Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3]. In Vitro:Crustecdysone induces cell autophagy and caspase-3 activity in the remodeling fat body of Drosophila[1]. In Vivo:Crustecdysone (5 or 10 mg/kg; i.p., once daily, for 6 weeks) reduces blood pressure and prevents dilated cardiac hypertrophy in SHR rats[2].

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