4'-Hydroxy flurbiprofen


CAS No. : 52807-12-2

52807-12-2
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Cat. No. : HY-118133
M.Wt: 260.26
Formula: C15H13FO3
Purity: >98 %
Solubility:
Introduction of 52807-12-2 :

4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM[1]. In Vitro:4'-Hydroxy flurbiprofen cannot inhibit COX-1 and COX-2–catalysed oxygenation of arachidonic acid, but inhibits cyclooxygenation of 2-arachidonoylglycerol (2-AG) completely at 300 µM and partially at concentrations of 100 µM and 30 µM[1].

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