Cyanidin (Chloride)

Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression^[1]. In Vitro: Cyanidin Chloride (IdB 1027) inhibits receptor activator of NF-κB ligand (RANKL)-induced NF-κB activation, suppresses the degradation of IκB-α and attenuates the phosphorylation of extracellular signal-regulated kinases (ERK). Cyanidin Chloride (IdB 1027) abrogates RANKL-induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1), and the expression of c-Fos^[1]. In Vivo: Cyanidin Chloride (IdB 1027) protects against OVX-induced bone loss in OVX-induced osteoporosis mouse model^[1].