CaMKP inhibitor (sodium)
CAS No. : 52789-62-5
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| Cat. No. : | HY-11000A |
| M.Wt: | 341.30 |
| Formula: | C10H8NNaO7S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
CaMKP inhibitor sodium (compound 5) is an inhibitor of Ca2+/neutral protein-dependent protein concentration (CaMKP) and its nuclear type (CaMKP-N) (IC50: 6.4 μM, CaMKP; 6.6 μM, CaMKP-N). CaMKP is one type of Ser/Thr protein, which can be passed through to remove the oxidized oxidized protein (CaMK). CaMKP inhibitor sodium inhibits CaMKP mediated phospho-CaMKI hydrolysis, unaffectes protein phosphoric acid 2C (PP2C) and calcineurin (CaN)[1].
IC50 & Target:IC50: 6.4 μM (CaMKP); 6.6 μM (CaMKP-N)[1]
In Vitro:CaMKP inhibitor sodium (10 μM; 6 h) inhibits CaMKP-N expressed in Neuro2a cells[1].
CaMKP inhibitor sodium (2.5 μM, 5 μM) inhibits CaMKP activity instead of PP2C activity in Neuro2a cells[1].
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