Beta-asarone

Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases^[1][2][3][4]. In Vitro: Beta-asarone (7.5-30 μg/mL; 25 h) can protect PC12 cells against Aβ_1-42 induced cytotoxicity and autophagy^[1].
Beta-asarone (100 μM; 2 h) inhibits the up-regulation of MALAT1 and α-synuclein expression in SH-SY5Y cells treated with MPP+ (HY-W008719)^[2]. In Vivo: Beta-asarone (intragastric administration; 10 mg/kg; 28 days) exhibits a neuroprotective effect in a mouse model of Parkinson's disease^[2].
Beta-asarone (oral administration; 12.5-50 mg/kg; 28 days) alleviates Aβ_1–42-induced apoptosis of hippocampal neurons in a rat model of Alzheimer's disease^[3].
Beta-asarone (intraperitoneal injection; 10-30 mg/kg; single dose) has anti-inflammatory and protective effects in a rat model of myocardial ischemia-reperfusion^[4].