Methyl 2-amino-5-bromobenzoate

Methyl 2-amino-5-bromobenzoate (Compound 8/12) is a pharmaceutical intermediate. Methyl 2-amino-5-bromobenzoate can be used to synthesize 2-benzamidobenzoic acid, a known FabH inhibitor. Derivatives of methyl 2-amino-5-bromobenzoate also inhibit PqsD, the pqs quorum sensing (QS) system, of Pseudomonas aeruginosa^[1]. In Vitro:Methyl 2-amino-5-bromobenzoate contains three key functional groups: 1. Aryl bromide, which can be used in various coupling reactions; 2. Ortho-position amino group, which allows multiple derivatization reactions and can be used to construct various nitrogen-containing heterocyclic backbones; 3. Methyl ester, which serves as a precursor for heterocyclic synthesis. Methyl 2-amino-5-bromobenzoate acts as a building block or intermediate in medicinal chemistry and can be used to synthesize a variety of active compounds.