Herbacetin
CAS No. : 527-95-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $380 | In-stock |
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| Cat. No. : | HY-N0240 |
| M.Wt: | 302.24 |
| Formula: | C15H10O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2]. IC50 & Target:IC50: Ornithine decarboxylase[2] In Vivo: Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO)[1]. Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; B.W.) decreases the number and size of polyps in APCMin+ mice with no overt toxicity[2].
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