Gluconate (sodium)
CAS No. : 527-07-1
(Synonyms: D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt)
| Size | Price | Stock |
|---|---|---|
| 10g | $25 | In-stock |
| 25g | $35 | In-stock |
| 50g | $42 | In-stock |
| 100g | $51 | In-stock |
| 500g | $82 | In-stock |
| 1kg | $99 | In-stock |
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| Cat. No. : | HY-B1092A |
| M.Wt: | 218.14 |
| Formula: | C6H11NaO7 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury[1][2][3][4][5][6][7].
In Vitro:Gluconate sodium (0.5-3 mM; 5 min) inhibits thrombin-induced arachidonic acid peroxidation and superoxide anion production in platelets, reduces platelet protein oxidation/nitration, and decreases carbonyl group generation, thiol oxidation, and nitrotyrosine formation[1].
In Vivo:Gluconate sodium (50 g/kg of basal diet; orally; 33 weeks) increases the cecal butyrate concentration in rats and reduces the tumor incidence and the average number of tumors in rats with induced colorectal cancer[2].
Gluconate sodium (50 mg/kg body weight; once a day for 5 weeks) regulates the changes in hematological parameters induced by Dimethylhydrazine (HY-W460407) in mice, reduces the levels of lipid peroxidation and nitric oxide (NO) in colon tissues, and improves the pathological changes of colon tissues[3].
Gluconate sodium (2500 ppm; in diet; p.o.; 15 days) increases the average daily gain of weaned piglets, reduces the feed-to-gain ratio, alleviates the intestinal injury induced by recombinant Escherichia coli, and improves the intestinal morphology[4].
Gluconate sodium (Calcium gluconate; 50 mg/kg; p.o.; 84 days) alleviates the symptoms of osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats, and inhibits joint stiffness and cartilage damage[5].
Gluconate sodium (Calcium gluconate; 12.5-50 mg/kg; i.p.; 30 min after modeling) alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice, and inhibits the infiltration of inflammatory cells and the release of inflammatory cytokines[6].
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