Calcimycin
CAS No. : 52665-69-7
(Synonyms: A-23187; Antibiotic A-23187)
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| 5mg | $220 | In-stock |
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| Cat. No. : | HY-N6687 |
| M.Wt: | 523.62 |
| Formula: | C29H37N3O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy[1][2][3][4][5]. In Vitro:Calcimycin (A-23187) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4]. In Vivo:Calcimycin (A-23187) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].
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