Huwentoxin-IV
CAS No. : 526224-73-7
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| Cat. No. : | HY-P1220 |
| M.Wt: | 4106.78 |
| Formula: | C174H278N52O51S6 |
| Purity: | >98 % |
| Solubility: | H2O |
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2]. IC50 & Target:IC50: 26 nM (Nav1.7), 150 nM (Nav1.2), 338 nM (Nav1.3), 400 nM (Nav1.4)[1]
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