Tryptophol

Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy^{[1][2][3][4][5][6][7][8][9][10][11][12]}. In Vitro:Tryptophol (25 μM) promotes the population density, biofilm formation and cell aggregation of the marine yeast Scheffersomyces spartinae and enhances its biocontrol effect against strawberry gray mold (Botrytis cinerea)^[1].
. Tryptophol (2 mM; 24 h) causes DNA damage in HepG2, A549 and THP-1 cells^[2].
Tryptophol (1-100 μM) inhibits the infection and replication of bacteriophage GVE2 against the thermophilic bacterium Geobacillus sp. E263^[3].
Tryptophol (0.25-2.00 mM; 24 h) is cytotoxic and genotoxic to human peripheral blood lymphocytes^[4].
Tryptophol (80 μg/ml; 12 h) induces apoptosis in U937 cells^[5].
Tryptophol (25-100 μM; 24 h) has anti-inflammatory activity in 3T3-L1 mouse adipocytes in vitro and reduces MCP-1 production in a dose-dependent manner^[6].
Tryptophol (0.02-0.1 mg/mL; 96 h) inhibits Cunninghamella blakesleeana biofilm growth and causes shedding of established biofilms^[7].
Tryptophol (3.8 mg/mL) lyses human red blood cells in pH and temperature- dependent manner^[8].
In Vivo:Tryptophol (100-300 mg/kg; i.p.) induces a sleep-like state and causes changes in body temperature in mice^[8].
Tryptophol (200-600 mg/kg; i.p.) induces sleep in mice in a dose-dependent manner^[9].
Tryptophol (50-100 mg/kg; i.p.; twice daily; 3 days) combined with ethanol increases the seizure susceptibility of mice^[10].
Tryptophol (200 mg/kg; i.p.) effectively suppresses Pentylenetetrazol and Picrotoxin (HY-101391) induced convulsion in mice^[11].