Xylometazoline


CAS No. : 526-36-3

526-36-3
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Cat. No. : HY-B0475A
M.Wt: 244.38
Formula: C16H24N2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 526-36-3 :

Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4]. In Vitro:Xylometazoline has affinity for α1A-adrenoceptor and α2B-adrenoceptor in HEK293 cells[2]. In Vivo:Xylometazoline (1 mg/mL, intranasal, single dose) improves sinusitis in rats[3].
Xylometazoline and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage[4].

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