Sesamolin

Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active^[1][2][3][4]. In Vitro:Sesamolin (0.5-50 μM, 1-2 h) reduces the release of LDH and ROS generation in H₂O₂ or hypoxia-stimulated PC12 cell, increases the cell viability, and exhibits antioxidant activity.
Sesamolin (0-10 μM, 5 days) inhibits RANKL-induced formation and differentiation of osteoclast in bone marrow macrophages, inhibits the bone resorption of osteoclasts through inhibition of NF-κB/MAPK signaling pathway, and suppression of c-Fos and NFATc1 expressions^[5].
In Vivo:Sesamolin (5 mg/kg, ip, every two days for 42 days) reduces the bone loss in mouse OVX-induced osteoporosis models^[5].
Sesamolin (60 mg/kg, po, twice a day for 3 weeks) improves metabolic disorders, attenuates hepatic steatosis, alleviates endotoxemia and systemic inflammation, alters the composition of gut microbiota, changes serum metabolites and metabolomics pathways, thereby ameliorating high-fat and high-fructose diet -induced non-alcoholic fatty liver disease in mouse models^[6].