Phellamurin


CAS No. : 52589-11-4

52589-11-4
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Cat. No. : HY-N3085
M.Wt: 518.51
Formula: C26H30O11
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 52589-11-4 :

Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity[1][2][3]. In Vitro: Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment leads to a repression of cell viability in U2OS and Saos-2?cells in a dose-dependent manner[1].
Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2?cells[1].
Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells[1]. In Vivo: Phellamurin (50?mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1].

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