Pranoprofen
CAS No. : 52549-17-4
| Size | Price | Stock |
|---|---|---|
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| 5g | $210 | In-stock |
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| Cat. No. : | HY-B0336 |
| M.Wt: | 255.27 |
| Formula: | C15H13NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases.?Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2]. In Vitro: Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells[1].Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells[3]. In Vivo: Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice[3].Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
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