Flavone

Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer^[1][2][3]. In Vitro:Flavone (10-80 μM; 24-72 h) inhibits the cell viability of the human esophageal squamous cell carcinoma cell line KYSE-510 in a dose- and time-dependent manner^[2].
Flavone (80 μM; 24 h) induces G2/M arrest in KYSE-510 cells, accompanied by upregulation of p21_waf1 mRNA and protein expression and downregulation of cyclin B1 expression^[2].
Flavone (80 μM; 24 h) triggeres apoptosis in KYSE-510 cells, as evidenced by DNA fragmentation, increases number of Annexin V/PI double-stained positive cells, and activation of caspase-9 and caspase-3^[2].
In Vivo:Flavone (25, 50, 100 mg/kg; intraperitoneal injection; once a day; for 10 consecutive days) significantly inhibits tumor growth in mouse S180 sarcoma and H22 liver cancer xenograft models, and enhances immune organ index and NK cell activity^[3].