Ethybenztropine
CAS No. : 524-83-4
(Synonyms: Ponalid; UK 738)
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| Cat. No. : | HY-118406 |
| M.Wt: | 321.46 |
| Formula: | C22H27NO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].
IC50 & Target:Muscarinic Receptor[1]
In Vitro:Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.
In Vivo:Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1].
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3].
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