SIS3
CAS No. : 521984-48-5
| Size | Price | Stock |
|---|---|---|
| 2mg | $66 | In-stock |
| 5mg | $140 | In-stock |
| 10mg | $215 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $922 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13013 |
| M.Wt: | 489.99 |
| Formula: | C28H28ClN3O3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1].
IC50 & Target:IC50: 3 μM (Smad3 phosphorylation)[1]
In Vitro: SIS3 (0.3-10 μM; for 1 hour) attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1].
SIS3 (0.1, 10, 50 μM; 30 min) significantly suppresses the expression of FN and α-SMA, but not that of Sphk2 provoked by TGF-β1[2].
SIS3 (10 μM; 24 hours) significantly reduces both α-SMA and palladin expression that is enhanced by TWEAK in Primary human dermal fibroblasts[3].
SIS3 significantly inhibits L4 development at five concentrations from as low as 2 μM to 50 μM (5 μM, 10 μM, 20 μM and 50 μM) in a dose-dependent manner[4].
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