Pinobanksin 3-acetate

Pinobanksin 3-acetate is a flavanone and flavonoid ester with antioxidant activity. Pinobanksin 3-acetate is naturally present in Sonoran propolis, honey, medicinal plants, and forestry coproducts of Pinus caribaea. Pinobanksin 3-acetate exerts anti-colorectal cancer activity by modulating proliferation, apoptosis, cell cycle, and Wnt signaling pathways. Pinobanksin 3-acetate can be used for the research of colon cancer^[1][2][3]. In Vitro:Pinobanksin 3-acetate does not inhibit proliferation of murine B-cell lymphoma M12.C3.F6 cells in an MTT assay and does not induce apoptosis in these cells^[1].
Pinobanksin 3-acetate (5-150 μg/mL; 24-72 h) potently inhibits proliferation of human colon cancer SW480 cells in a time- and dose-dependent manner, with IC₅₀ values of 163.61 μg/mL at 24 h, 40.72 μg/mL at 48 h, and 45.56 μg/mL at 72 h^[3].
Pinobanksin 3-acetate (50, 100 μg/mL; 24 h) dose-dependently increases the apoptotic rate of human colon cancer SW480 cells^[3].
Pinobanksin 3-acetate (100 μg/mL; 24 h) alters the expression of 4912 genes in human colon cancer SW480 cells, with differential expression enriched in pathways linked to cell proliferation, apoptosis, and colorectal carcinogenesis^[3].