Broxyquinoline
CAS No. : 521-74-4
(Synonyms: Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline)
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| Cat. No. : | HY-B1212 |
| M.Wt: | 302.95 |
| Formula: | C9H5Br2NO |
| Purity: | >98 % |
| Solubility: | H2O : 0.67 mg/mL (ultrasonic);DMSO : 31.25 mg/mL (ultrasonic) |
Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases[1][2]. In Vitro:Broxyquinoline (1 mM, 10 μM, 44 h) has almost no active effect on Human ileocaecal colorectal adenocarcinoma (HCT-8) cells[1]. Broxyquinoline (0-1.0 mM, 44 h) exhibits antiparasitic activity in vitro[1]. Broxyquinoline (10 μM, 72 h) does not show significant toxicity to Vero cells and exhibits activity against severe fever with thrombocytopenia syndrome virus (SFTSV) [2]. In Vivo:A 5:1 mixture of broxyquinoline and broxaldin (0.1 g/kg, p.o., once daily for 32 days) did not cause any histological changes in the visceral organs of rats[3].
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