Physcion

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC₅₀ and K_d values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells^{[1][2][3][4][5]}. IC50 & Target:IC50: 38.5 μM (6-phosphogluconate dehydrogenase)^[1]
Kd: 26.0 μM (6-phosphogluconate dehydrogenase)^[1] In Vitro:Physcion (10 or 20 μM, 48 h) induces apoptosis and autophagy in human nasopharyngeal carcinoma (CNE2 cells)^[2].
Physcion (10-40 μM, 24 h) attenuates OGD/R (oxygen-glucose deprivation/reperfusion)-induced neuronal damage and inflammatory response in SH-SY5Y cells^[3].
In Vivo:Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model^[3].
Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens^[4].