Isoxanthohumol

Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases^{[1][2][3][4][5]}. In Vitro:Isoxanthohumol (0-100 μM; 20 min-6 d) reduces the viability, induces apoptosis of mature 3T3-L1 adipocytes, and inhibits the differentiation of 3T3-L1 preadipocytes. The mechanisms are associated with ROS generation and mitochondrial dysfunction^[1].
Isoxanthohumol (2.5-50 µg/mL) inhibits Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum with EC₅₀ values of 4.32, 16.50, and 14.52 µg/mL, respectively^[2].
Isoxanthohumol (1.6-100 μM; 0-7 d) suppresses the proliferation, adhesion, migration, invasion, and colony formation, induces apoptosis and autophagy, and downregulates the integrin signaling pathway in B16-F10 cells^[3]. In Vivo:Isoxanthohumol (20 mg/kg; oral administration; 18 days) exhibits antimetastatic activity in a B16-F10 mouse tumor model^[3].
Isoxanthohumol (60 mg/kg; oral gavage; 8 days) shows ameliorative effects in a DSS (HY-116282C)-induced mouse colitis model^[4].