Sciadopitysin
CAS No. : 521-34-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $202 | In-stock |
| 20mg | $343 | In-stock |
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| Cat. No. : | HY-N2119 |
| M.Wt: | 580.54 |
| Formula: | C33H24O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2]. In Vitro: Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2]. In Vivo: Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2].
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