Hesperetin
CAS No. : 520-33-2
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|---|---|---|
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| 100mg | $80 | In-stock |
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| Cat. No. : | HY-N0168 |
| M.Wt: | 302.28 |
| Formula: | C16H14O6 |
| Purity: | >98 % |
| Solubility: |
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor[1][2][3][4].
In Vitro:Hesperetin (Compound HET) (100 μM) results in strong or moderate inhibition on 10 tested rhUGT isoforms[2].
Hesperetin (100-800 μM, 24-48 h) significantly reduces the viabilities of U-251 and U-87 cells in a time- and concentration-dependent manner[4].
Hesperetin (200-400 μM, 24 h) significantly increases the proportion of apoptotic cells in a dose-dependent manner in U-251 cells[4].
In Vivo:Hesperetin (Compound Hp) (40 mg/kg, p.o., 21 d) reversed the activities of AChE to near normal in Cd-exposed rats[3].
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