Nepetin
CAS No. : 520-11-6
(Synonyms: 6-Methoxyluteolin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
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| Cat. No. : | HY-N2572 |
| M.Wt: | 316.26 |
| Formula: | C16H12O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].
In Vitro: Pretreatment with Nepetin dose-dependently inhibited IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43, 3.42 and 4.17 μM, respectively[1].
Nepetin (2.5-10 μM; 25 hours; ARPE-19 cells) treatment suppresses IL-1β-induced cytokine (IL-6, IL-8 and MCP-1) expression at mRNA level in ARPE-19 cells[1].
Nepetin (2.5-10 μM; 1.5 hours; ARPE-19 cells) treatment dose-dependently inhibits phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Nepetin decreases the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells[1].
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