Cycloleucine
CAS No. : 52-52-8
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|---|---|---|
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| 10g | $19 | In-stock |
| 25g | $42 | In-stock |
| 100g | $167 | In-stock |
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| Cat. No. : | HY-30008 |
| M.Wt: | 129.16 |
| Formula: | C6H11NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic);H2O : 20 mg/mL (ultrasonic) |
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4].
IC50 & Target: Ki: 600 μM (NMDA)[1][2]
In Vitro: Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts[5].
Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[5].
Cytostatic (10 µg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines[5].
In Vivo: Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3].
Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice[6].
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