Aldosterone
CAS No. : 52-39-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $610 | In-stock |
| 10mg | $1125 | In-stock |
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| Cat. No. : | HY-113313 |
| M.Wt: | 360.44 |
| Formula: | C21H28O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Ethanol : 33.33 mg/mL (ultrasonic) |
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
In Vitro: Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3].
In Vivo: Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4].
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5].
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