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| Cat. No. : | HY-116778 |
| M.Wt: | 368.46 |
| Formula: | C20H32O6 |
| Purity: | >98 % |
| Solubility: |
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A2 production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury[1][2]. In Vitro:Prostaglandin G2 (0.6-1 μg) incubated with Indomethacin (HY-14397)-pretreated washed human platelets generates an unstable rabbit aorta contracting factor (thromboxane A2) with a half-life of 34 sec at 37 °C that induces strong contraction of isolated rabbit aorta strips[1]. In Vivo:Prostaglandin G2 (10 μg/mL; local administration under cranial window; single exposure for 15 min) induces cerebral arteriole injury in anesthetized cats[2].
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