Pipemidic acid
CAS No. : 51940-44-4
| Size | Price | Stock |
|---|---|---|
| 25mg | $25 | In-stock |
| 50mg | $35 | In-stock |
| 100mg | $50 | In-stock |
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| Cat. No. : | HY-B1210 |
| M.Wt: | 303.32 |
| Formula: | C14H17N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic);1M NaOH : 100 mg/mL (ultrasonic;adjust pH to 12 with NaOH) |
Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections[1][2].
In Vitro:Pipemidic acid is an inhibitor of DNA gyrase that is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA[2].
In Vivo:Pipemidic acid (50 mg/kg) is absorbed well by the oral route, and the peak levels in plasma ranged from 4 to 12 μg/mL in mice, rats, dogs, monkeys[3].
The mean lethal dose of Pipemidic acid after a single oral dose was more than 16000 mg/kg in mice[3].
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