Tasisulam (sodium)


CAS No. : 519055-63-1

(Synonyms: LY 573636 (sodium))

519055-63-1
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Cat. No. : HY-14804A
M.Wt: 437.09
Formula: C11H5BrCl2NNaO3S2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 519055-63-1 :

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1]. In Vitro: Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].
Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1].

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