Tasisulam
CAS No. : 519055-62-0
(Synonyms: LY 573636)
| Size | Price | Stock |
|---|---|---|
| 100mg | $150 | In-stock |
| 250mg | $337 | In-stock |
| 1g | $522 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-14804 |
| M.Wt: | 415.11 |
| Formula: | C11H6BrCl2NO3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1].
In Vitro: Tasisulam (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].
Tasisulam also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1].
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