Etofylline
CAS No. : 519-37-9
(Synonyms: 7-(β-Hydroxyethyl)theophylline)
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|---|---|---|
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| Cat. No. : | HY-B1209 |
| M.Wt: | 224.22 |
| Formula: | C9H12N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos[1][2][3].
In Vivo:Etofylline (1 mg/kg, intratracheal administration) can be delivered into rat lungs after being coated with Mannose-anchored N,N,N-trimethyl chitosan nanoparticles and is safe for pulmonary administration[2].
Etofylline (100-1000 mg/L, incubate in diluent; 24, 48 and 72 h post fertilization) affects the locomotor activity and development of zebrafish embryos[3].
Pharmacokinetic parameters of ethoxyphylline (150 mg/kg within 5 minutes) in rabbits after intravenous injection [1]
| Compartment | β(h-1) | α(h-1) | γ(h-1) | Vdβ | Cl(1/kg/h) | t1/2 (h) | 1/MRTb(h-14) | Vdss (1/kg) | MRTb(h-14) |
| two | 0.41±0.09 | 4.72±1.57 | / | 1.41±0.31 | 0.37±0.12 | 1.7 | / | / | / |
| three | 0.39±0.13 | 1.68±0.87 | 19.99±6.78 | 1.03±0.34 | 0.39±0.08 | 1.8 | / | / | / |
| none | / | / | / | / | 0.37±0.08 | / | 0.59±0.24 | 0.71±0.30 | 1.94±0.7 |