ESI-05
CAS No. : 5184-64-5
(Synonyms: NSC 116966)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $116 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $352 | In-stock |
| 100mg | $605 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117656 |
| M.Wt: | 274.38 |
| Formula: | C16H18O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders[1][2].
IC50 & Target:IC50: 0.43 μM (EPAC2)[1]
In Vitro:ESI-05 (0.01 μM -1 nM) inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 0.43 μM, but completely ineffective in suppressing EPAC1 GEF activity[1].
ESI-05 (1, 5, 10, and 25 μM; 5 min) selectively modulates EPAC2 activation in living cells[1].
In Vivo:ESI-05 (2, 4, and 8 mg/kg) decreases neuronal apoptosis by inhibiting the p38/BIM pathway in vivo[2].
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