Corydaline
CAS No. : 518-69-4
(Synonyms: (+)-Corydaline; Corydalin)
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| Cat. No. : | HY-N0923 |
| M.Wt: | 369.45 |
| Formula: | C22H27NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].
IC50 & Target: IC50: 226 µM (AChE)[1]; 25.23 µM (Enterovirus 71)[2]
Ki: 1.23 µM (μ-opioid receptor)[3]
In Vitro: Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro[2].
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner[2].
In Vivo: Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior[3].
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