Cefroxadine

Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 10⁶ μg/mL. Cefroxadine can be used for the research of infection^[1]. In Vitro:Cefroxadine (10⁶-10⁸ μg/mL; overnight) shows antibacterial activities against S. aureus, E. coli, S. typhi, S. paratyphi, S. schottmuelleri, K. apneumoniae and P. mirabilis with MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 10⁶ μg/mL^[1]. Cefroxadine (10⁴-10⁸ μg/mL; overnight) shows antibacterial activities against 100 E. coli strains with MIC₅₀ and MIC₇₅ values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively^[1]. In Vivo:Cefroxadine (0-30 mg/kg; p.o. 0 and 3 h after infection) shows a better effect than cephalexin in vivo^[1].