Ki 23057
CAS No. : 516523-31-2
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| Cat. No. : | HY-18187 |
| M.Wt: | 501.62 |
| Formula: | C30H35N3O4 |
| Purity: | >98 % |
| Solubility: |
Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models[1].
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